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Wolfson Children's Hospital Bone and Soft Tissue Cancer

Bone Tumors and Soft Tissue Sarcomas

Our world-renowned pediatric oncology team at Wolfson Children’s is highly experienced in treating bone and soft tissue cancers in infants, children, teens and young adults. From diagnosis and treatment to management and beyond, we improve outcomes and outlooks.

Cancer Center

Wolfson Children's Hospital provides hematology (blood disorders) and oncology (cancer) services in partnership with Nemours Children's Health, Jacksonville and the University of Florida College of Medicine, Jacksonville. Learn more

Why Wolfson

  • Wolfson Children’s Hospital has been ranked by U.S. News & World Report as one of the 50 best children’s hospitals for cancer care.
  • Together with Nemours Children's Specialty Care, we are an Accredited Pediatric Cancer Program by the American College of Surgeons.
  • Our team is involved in research, studies and clinical trials, and provides cutting-edge treatment options and protocols based on the latest medical advancements.
  • We participate in more than 80 pediatric cancer clinical trials as a member of the Children’s Oncology Group, and almost all of our patients receive treatment using research protocols.
  • All patients are evaluated for available clinical trials.

Care You Can Trust

The Cancer Center at Wolfson Children’s Hospital offers children of all ages access to nationally known pediatric cancer specialists. We work together to carefully coordinate each treatment plan, because while we’re curing kids, we also want to protect their developing bodies and overall health.

Conditions We Treat

  • Ewing sarcoma
  • Osteosarcoma
  • Soft tissue sarcoma
  • Rhabdomyosarcoma

Cancer Center

University of Florida College of Medicine, Jacksonville Nemours Children's Health, Jacksonville Wolfson Children’s Hospital

Wolfson Children's Hospital provides hematology (blood disorders) and oncology (cancer) services in partnership with Nemours Children's Health, Jacksonville and the University of Florida College of Medicine, Jacksonville. Learn more


Musculoskeletal tumors can be benign or malignant. To make a diagnosis, our pediatric tumor specialists may need to run several tests, such as:

  • Diagnostic imaging tests, including X-rays, ultrasound, MRI, CT and PET scans
  • Bone scans
  • Biopsies
  • Bone marrow aspiration
  • Genetic testing

Treatments We Offer

The survival rate for pediatric cancer is more than 80 percent, which means most children with these types of cancers get better. If a tumor is benign, surgery is the primary treatment. Tumors that are cancerous usually require a mixture of surgery, chemotherapy and/or radiation, including proton therapy.

Wolfson Children's Hospital Bone and Soft Tissue Cancer

Programs and Services

Proton Therapy

Wolfson Children’s partners with University of Florida (UF) Proton Therapy Institute in Jacksonville. Children come from all over the world to receive advanced treatment at the institute, which is one of the largest pediatric proton therapy centers in the world. Because proton therapy is so precise, treatment with it allows for higher doses of radiation to target tumors with less damage to surrounding, healthy tissue and it can produce successful outcomes.


At Wolfson Children’s, we have the latest advanced diagnostic technology, which allows us to make an accurate diagnosis even more quickly. Our radiology team is trained in “Image Gently” protocols, which means we’re committed to using the smallest radiation dose possible to minimize exposure for testing purposes.

Clinical Trials

Children with cancer benefit from our long-time participation in research. Through our work with the Children’s Oncology Group and other pediatric cancer research groups, we have access to the latest clinical protocols and experimental therapies to give children the best chance for a positive outcome.

Bone Marrow Transplant

Wolfson Children's Hospital Blood and Marrow Accredited

The Blood and Marrow Transplantation Center at Wolfson Children’s Hospital, a collaboration with Nemours Children’s Health Jacksonville and Mayo Clinic, brings children from all over the world to receive care. Our experience and cutting-edge practices can be life saving for a child.

Give to Wolfson Children's Hospital

Celebrating New Beginnings:  Reaching the Checkered Flag

After a child receives a bone marrow transplant, they will be in the hospital for a while. So, when the day comes to finally go home, it’s a day worth celebrating. At Wolfson Children’s, we celebrate important milestones like this together with our patients. A parade lap around the pediatric oncology floor that includes the patient’s favorite music culminates at a checkered flag that each transplant graduate signs and dates.

Adolescent and Young Adult (AYA) Oncology Program

Adolescents and young adults with cancer experience unique challenges during this time in their lives when they are becoming more independent. We offer an approach to care that is based on their age and emotional needs by enabling them to connect with other teens going through similar treatment. For information, call 904.697.3600.

Our Team

Children’s growing bodies deserve care from the most practiced specialists around, working as one team to deliver outstanding care. Your child’s care team includes orthopedic surgeons, oncologists, radiotherapists, pathologists, radiologists, specialized nurses, psychosocial clinicians and physical therapists who work together to create a plan for initial treatment and ongoing after care to meet the specific needs of your child.


The Cancer Center serves children from North Florida, South Georgia and beyond. Wolfson Children's is located on the south bank of the St. Johns River in downtown Jacksonville and is connected to Nemours Children's Health via Kids Walk. Ronald McDonald House is next to Nemours Children's Health. Follow-up care is provided at our Brunswick and Daytona specialty centers.

Kids Walk pedestrian bridge that joins Wolfson Children's Hospital to Nemours Children's Health

Patient Stories

Teen Who Battled Muscle Cancer Now Running Marathons

After fighting stage IV rhabdomyosarcoma, Marissa is a survivor who knows what real endurance is.

Read Marissa's Story